Modafinil Australia Online a wakefulness-promoting medication, affects dopamine levels in the brain, but its precise mechanism of action is not fully understood. However, it is believed to primarily act on dopamine transporters, which are proteins responsible for removing dopamine from the synaptic cleft, the space between neurons. By inhibiting the reuptake of dopamine, modafinil increases the concentration of dopamine in the brain, particularly in areas associated with wakefulness and alertness, such as the hypothalamus and prefrontal cortex.